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A UK research team Anglia Ruskin University found the most widely used artificial sweeteners Saccharin, sucralose and aspartame induce intestinal bacteria to invade intestinal cells to be able. The results were recently presented in the International Journal of Molecule Sciences.
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“There are many Concerns about the consumption of artificial sweeteners, with some studies showing that sweeteners can affect the layer of bacteria that support the gut, known as the intestinal microbiota, “said the study’s lead author, Dr. Havovi Chichger.
Previous studies have shown this artificial sweeteners can change the number and type of bacteria in the gut. The current research is the first study that shows the possible pathogenic effects that favor the disease of artificial sweeteners saccharin, sucralose and aspartame. In particular, sweeteners interact with intestinal bacteria such as Escherichia coli (E. coli) and Enterococcus faecalis (E. faecalis). Apparently, sweeteners can make bacteria pathogenic, that is, exciting, and disease-promoting.
“Our study is the first to reveal some of the most common sweeteners in foods and beverages they cause normal, healthy intestinal bacteria to become pathogenic“, confirms Dr. Chichger. These disease-friendly changes are characterized by increased biofilm formation and increased adhesion and invasion of intestinal bacteria to human intestinal cells.
Cola light and Co .: the intestinal wall is especially affected
The epithelial cells of the intestine, that is, the cells that line the intestinal wall, are especially affected. Due to the changes caused by sweeteners, intestinal bacteria can attach to intestinal cells, penetrate them, and kill them.
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“These changes can cause our own intestinal bacteria to penetrate our intestines and damage them, which can be associated with infections, sepsis, and multiple organ failure,” the study author explains.
From previous studies it is already known that bacteria like E. faecalis can cross the intestinal wall and enter the bloodstream. This is related to an accumulation of bacteria in the lymph nodes, liver and spleen, which increases the risk of various diseases, including infections and blood poisoning.
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The researchers found that even two cans of diet soda like Cola-Light contain a concentration of sweeteners that significantly increase the pathogenicity of both E. coli. Coli as of E. Faecalis.
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On the one hand, the harmful effects of sweeteners are due to the increased formation of biofilms in the intestine. In these biofilms, bacteria grow faster and are more likely to secrete toxins. On the other hand, there is an increased risk of penetration of pathogenic intestinal bacteria into so-called Caco-2 cells, located in the intestinal wall.
According to the study, the three sweeteners examined, namely saccharin, sucralose and aspartame, had a similar harmful effect on the intestinal flora, although saccharin had no significant effect on the invasion of saccharin. ‘E. Coli.
“We know that excessive sugar consumption is an important factor in the development of diseases such as obesity and diabetes,” says Dr. Chichger. Therefore, it is important to understand how sweeteners, as an alternative to sugar, affect health.
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