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Primary stem cells in the patient's brain



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Japanese researchers injected so-called "iPS" stem cells into the brain of a patient with Parkinson's disease. This clinical trial aims to test whether these cells can regenerate neurons of dopamine and alleviate symptoms.

The teamKyoto University They injected 2.4 million pluripotent cells, capable of giving any type of cell, in the left part the brain, during the last month's cost-cutting operation. The man was well tolerated in the 1950s and will now be under surveillance for two years, Kyoto University reported.

If there is no problem in the next six months, the researchers will then implant an additional 2.4 million cells this time in the right part of the patient's brain. It is expected that these iPS cells will grow from healthy donors neurons dopamine manufacturers, neurotransmitters involved in engine control.

In July, Kyoto University announced the holding of this clinical trial with seven participants aged 50 to 69 years. "I welcome patients for their courage and decisive participation", wrote Professor Jun Takahashi, quoted by NHK Public Television on Friday.

Pluripotent cells generate new neurons

Parkinson's disease is marked by the degeneration of dopamine neurons and results symptoms which are progressively worsening, such as tremors, stiffness of the extremities and reduced body movements. It affects more than ten million people around the world Parkinson's disease foundation USA. Therapies currently available "Improve symptoms without slowing progression of disease"explains the foundation.

This test follows an experiment on monkeys with stem cells of human origin that have improved the ability to move receive Parkinson's disease, according to a study published at the end of August 2017 in a scientific journal the nature. Survival of interlaced cells by injection into the primate brain was observed for two years, with no tumor.

induced pluripotent stem cells (iPS for induced pluripotent stem cells), the adult cells were returned to an almost embryonic state by four genes (usually inactive in adult cells). This genetic manipulation gives them the ability to produce any kind cell (pluripotence), towards the site of the body where they are then transplanted. The use of iPS cells is not a basic ethical problem, unlike stem cells taken from Embryos people.

What to remember

  • Scientists from the University of Kyoto injected 2.4 million pluripotent cells into the brain of the patient.
  • These cells from healthy donors will need to regenerate neurons of dopamine.
  • In total, the clinical trial should include seven patients.

Parkinson's disease: stem cells reveal back pain

Article from Tokyo – AFP published on February 25, 2012

Monkeys develop the equivalent of Parkinson's disease showed improvement in their symptoms after injection into the human stem cell brain. The technique could be examined by people from 2015.

Monkeys who suffer from Parkinson's disease have made significant progress after implantation of human stem cells into their brain, Japanese researchers said on Wednesday.

Four monkeys whose limbs spasmodically moved (a common symptom syndrome from the Parkinson'sAnd whoever was trying to control his bodies, he showed signs of improvement three months after the operation, said Jun Takahashi, a professor ofKyoto University, one of the authors of the study published in Parkinson's Disease Journal.

Six months later transplantationfour tested primates could again walk in their cage, he added.

Jun Takahashi stated that at the time of realization 35% stem cells were dopamine neurons, and about a dozen of them are still alive a year later. In order to improve healing efficiency, he would like to increase this survival rate to 70%. He hopes to be able to carry out this experiment on humans already in 2015. " First, we need to increase the number of dopaminamin neurons implant, in order to reduce the risk tumor " postoperative, he explained.

Pluripotent stem cells induced in humans

In this experiment with the monkey was used by Jun Takahashi and his team embryonic stem cellsbut in the case of medical experience, researchers think they are using them induced pluripotent stem cells (IPSCs), created by implanting four types of genes into human skin cells for reprogramming. These induced iPSCs are thus generated almost to the embryonic stage (undifferentiated).

Use embryonic stem cells, which many scholars consider to be very promising, is opposed. Religious groups consider the culture of these cells unethical, emphasizing it destruction of embryos. In Japan, however, nothing prohibits the use of these cells for scientific research.

Parkinson's disease is one of the main ones neurodegenerative diseasesafter Alzheimer's disease. It is also one of the most common causes of motor disability accident cerebrovascular disease.

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