Angiotensin converting enzyme inhibitors are a group of medicines used to treat cardiac insufficiency, high blood pressure (hypertension), or a reduction in complications of myocardial infarction (heart attack). These drugs are also useful for slowing down the progression of kidney disease in patients with chronic kidney disease or kidney disease in patients with diabetes. The mechanism of action of angiotensin converting enzyme inhibitors is to reduce the amount of angiotensin II produced. Angiotensin II has an effect on the body to increase kidney pressure, blood volume and blood pressure.
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Angiotensin converting enzyme inhibitors expand blood vessels by reducing the amount of angiotensin II in the body. This also increases the amount of urine produced by the kidneys. This results in lowering the pressure in the kidney, decreasing the blood volume and blood pressure. There is a decline in the levels of aldosterone and noradrenaline due to the inhibition of angiotensin II inhibitors of angiotensin converting enzyme that helps to reduce blood pressure. Angiotensin converting enzyme inhibitors also increase bradykinin that expands blood vessels, thereby reducing blood pressure. This also causes several side effects, depending on the type of dependent angiotensin converting enzyme inhibitors. Side effects include swelling of the face or respiratory tract (angioedema), decreased renal function, dizziness, high potassium levels (hyperkalemia), dry cough, and low blood pressure (hypotension).
An increase in the prevalence of high blood pressure is a major factor that leads to the decline in angiotensin converting enzyme inhibitors. According to the World Health Organization, more than 1 out of 5 adults suffer from high blood pressure globally. Complications of high blood pressure cause about 9.4 million deaths worldwide every year. An increase in cardiac insufficiency prevalence also triggers the market of angiotensin converting enzyme inhibitors. According to the Centers for Disease Control and Prevention (CDC), about 5.7 million adults in the United States suffer from heart failure each year, almost half of these people die within five years of diagnosis.
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The angiotensin converting enzyme inhibitor market can be segmented based on the type of disease, the dosage form, and the distribution channel. Regarding the type of disease, the angiotensin converting enzyme inhibitor market may be divided into heart failure, high blood pressure (hypertension), heart attack, and kidney pain. Based on dosage forms, the global market for angiotensin converting enzyme inhibitors can be categorized into oral tablets and an oral solution. Based on the distribution channel, the angiotensin converting enzyme inhibitor market can be classified in online pharmacies, retail pharmacies and hospital pharmacies.
The geographic, global market for angiotensin converting enzyme inhibitors can be segmented into Latin America, the Asia Pacific, Europe, North America and the Middle East and Africa. North America had the largest market share of antibodies to inhibit angiotensin converting in 2016. An increase in prevalence of heart attack, heart attack and high blood pressure exacerbates the market of angiotensin converting enzyme inhibitors in the region. Europe was the second largest market share in 2016. An increase in the prevalence of kidney disease and high blood pressure in the region contributes to the growth of markets in the region. It is expected that the angiotensin converting enzyme inhibitors market in Asia Pacific will be stimulated by the increase of government initiatives for the health care sector, especially in countries like India and China. It is envisaged that the global market for angiotensin converting enzyme inhibitors in the Middle East and Africa will be encouraged by initiatives taken by governments in the health sector. It is anticipated that the market for angiotensin converting enzyme inhibitors in Latin America is experiencing strong growth during the foreseen period thanks to government initiatives for heart disease in the region.
The key players in the global market for angiotensin converting enzyme inhibitors include Bristol-Miers Skuibb, Par Pharmaceuticals Inc., UCB, Inc., Pfizer, Inc. and AstraZeneca.