Tuesday , September 27 2022

The effects of linoleic acid on the inflammatory response depend on genes – ScienceDaily



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The effects of linoleic acid on the human body depend to a large extent on genes, a new study from the University of Eastern Finland shows. Linoleic acid is an essential fatty acid. People who carry different variants of the FADS1 gene had a different inflammatory response and different changes in their glucose levels as they drank when they supplemented their diet with sunflower oil rich in linoleic acid. This was the first time that these associations were studied in humans.

According to Maria Lankinen postdoctoral researcher at the University of East Finland, the findings justify the speculation that if recommended intake of linoleic acid, and possibly other fatty acids, they should be adapted to adapt to the genes of a person.

"However, more research is needed before formulating recommendations based on genes," says Lankinen postdoctoral researcher.

The FADS1 gene regulates the metabolism of the body's fatty acid and also plays an important role in the metabolism of glucose. The diet of a person, in turn, has an important impact on the concentrations of different fatty acids in the body. Linoleic acid is found in plant-based oils, nuts and seeds, and is the most omega-6 polyunsaturated fatty acid. High intake and high levels of linoleic acid in the blood are s & They have been associated with a reduced risk of type 2 diabetes and cardiovascular disease. On the other hand, however, the metabolites of linoleic acid can mediate the inflammation, reason why a high intake of linoleic acid is considered a plausible factor that contributes to the ########################################### low grade inflammatory state. According to the recently published study, these contradictory observations could be explained by genetic differences.

The study explored whether specific mutations in rs174550 of the FADS1 gene modifies the effects of linoleic acid on the composition of the fatty acid and on the levels of glucose, insulin and CRP in weakness. These were analyzed in more than 1,300 middle-aged men who participated in the METSIM study (Metabolic Syndrome in Men). In addition, 60 men participated in the FADSDIET intervention for operators of two different genetic variants. Over four weeks, they completed their daily diet using 30-50 ml of sunflower oil rich in linoleic acid. The selection of participants from their genes is a unique research environment that provides information on the interactions of the diet with genes.

The findings indicate that the effects of linoleic acid on the human body depend to a large extent on which variant of the FADS1 gene generates a person. This affects, for example, how effective a linoleic acid supplement can lower the levels of glucose in weakness. Additionally, depending on the gene variant, the increase in linoleic acid intake may cause CRP levels of a person to go up or down. The variant of the FADS1 gene also had an effect on the levels of inflammatory mediators, which are created from the metabolites of linoleic acid and other omega 6 fatty acids.

The study was carried out in collaboration with Karolinska Institutet, and the results were published at the American Journal of Clinical Nutrition.

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Materials provided by University of eastern Finland. Note: Content can be edited for style and duration.

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