HALIFAX – Researchers have discovered that fragility is a key risk factor for dementia.
A study by Dalhousie University of Halifax and the Rush University of Chicago found that fragility aggravates the effects of plaques and embolics: the confusing nerves of the proteins that accumulate in some brains.
He found that fragility could even be a risk factor alone, and resistance can be the most important protection against Alzheimer's disease and dementia.
The first study, published in Lancet Neurology, examined the autopsy and clinical data of 456 people.
The subjects were part of the Rush University Memory and Aging Project, and its fragility was measured in an index developed in Dalhousie that classifies physical health deficits and the ability to function.
Researchers say that older homes are key to promoting preventative measures such as social interaction, physical activity and healthy eating.
"We have confirmed that there are many people with many plaques and embolisms that do not have dementia," said Lindsay Wallace, doctoral candidate in Dalhousie and co-author of the article, in a statement.
"These people were less fragile. On the contrary, there were people with very few plates and tangles that had severe dementia. These people were very fragile, in fact, they were more fragile than people who had many plaques and deviousness and dementia."