Monday , September 26 2022

Spanish researchers determine the role of cholecystectomy in the emergence of diarrhea for bile acids



Up to two thirds (70%) of patients with chronic watery diarrhea and previous cholecystectomy have diarrhea for bile acids, according to a Spanish research published in the journal "Aliment Pharmacol Ther & # 39;".

The study, coordinated by Fernando Fernández Bañares, a researcher at the CIBER of Hepatic and Digestive Diseases (CIBEREHD) at the Fundació Mútua Terrassa, has carried out a systematic review and meta-analysis, including a series of his own, with the largest sample size up to now published on the role of cholecystectomy (surgery for the removal of the gallbladder) in the appearance of diarrhea for bile acids.

Post-cholecystectomy diarrhea is a complication that appears in 9 percent of patients after the intervention. So far, a limited number of small-sized studies suggest that diarrhea for bile acids is common in patients with chronic watery diarrhea and previous cholecystectomy.

"The response to treatment with cholestyramine in these patients was 79 percent, which confirms that the cause of diarrhea is malabsorption of bile acids. These findings have implications for future studies and clinical practice guides." , says Dr. Fernández Bañares.

The study also had the participation of the CIBEREHD group, led by Javier Gisbert at the Hospital de la Princesa de Madrid.

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