Tuesday , September 27 2022

Resistance to antibiotics serious health care to Canadians, experts say



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With the cold and season of the flu over us, some patients will undoubtedly go to their doctors seeking antibiotic prescription, although drugs are useless against such viral infections.

It is such abuse and excessive use that has helped a growing number of bacteria become resistant to most or all of the antibiotics – the doctors of the phenomenon call the crisis because there are no new drugs in the pharmaceutical pipeline to replace them.

And not just the patients and doctors who are guilty: decades of liberal use of antibiotics to promote the health of animal farms have moved to our tables and polluting the environment from the present drugs have led to so-called superbugs like MRSA and VRE that have developed resistance to their effects.

But all this is basically the fact that antimicrobial resistance is a natural phenomenon, the process of bacterial evolution that has emerged for thousands of years, said Gerri Vright, director of the Institute for Research on Infectious Diseases at McMaster University.

"What is frustrating is, of course, that our excessive use of antibiotics when we do not need to contribute to this selection," he said from Hamilton, Ont. "If we create a situation where we use antibiotics when we do not need, then we create selective pressures that increase the chances of bacteria that develop into resistant organisms.

"And that's the question we're now discovering, that there are more and more bacteria in the clinic where we use a lot of antibiotics that do not respond to all the drugs we have at our disposal."

The difficulty is that the pharmaceutical industry no longer invests time or money in the search for a new antibiotic, said Wright, explaining that science is not only "really tough," but the discovery of any kind is indirectly expensive.

Drug manufacturers are unwilling to make an average of $ 1 billion in the development of antibiotics that can heal the infection for five to ten days, when they can put their resources into medicines for conditions like high cholesterol or blood pressure, which are typically taken lifelike.

Add to this the fact that the new antibiotic may have a limited shelf life, because errors that need to be treated can develop resistance and there is little incentive, Dr. Andrev Morris, director of the antimicrobial management program at Sinai Health System and the Universiti Health Network in Toronto.

Morris said that the lack of new antibiotics was also a civil society issue because people took it for granted that these drugs were widely available since the 1940s.

"So we can have a cancer medicine that can extend one's life for six months and it can cost between $ 5,000 and $ 100,000," he said, "on the other hand, we can have an antibiotic that will completely save someone's life and get it if this medicine costs more than $ 1,000. "

& # 39; Affects Everything, Everywhere & # 39;

A national online survey showing Canadian knowledge of this problem has shown that 60 percent of respondents mistakenly believe that antibiotic resistance means that a person with an infection is resistant to medication. Published for the World Week of Antibiotic Resistance, ending on Sunday, the Leger survey of more than 1,500 Canadian residents aged 18, also found that 44 percent saw resistance as a concern for developing countries.

"Antimicrobial resistance affects everyone, everywhere, and this includes Canada, where there is more serious concern," Morris said. "It's really a global health issue that requires collective action."

By 2050, drug resistant infections are predicted to lead to an estimated 2.4 million excessive deaths in developed countries, according to a recent OECD projection, which represents nations such as Canada, Australia, the United States and UK

Other experts warn that by that day, the annual death penalty for antibiotic resistance will rise to 10 million worldwide – carcinogenic cancer – and cost the global economy of 100 trillion US dollars.

"The worst thing that could happen is that we will finish again in the same way as it was in the 1920s and 1930s," before penicillin was discovered, when more people died from infection than any other single cause, he said Wright.

"Today in Canadian hospitals people are dying today who did not die five years ago [their] infection, "said Wright.

"It is not necessarily thousands of people, people are not being removed dead on the street, there is no zombie apocalypse," he said.

"But we have people in our hospitals that we could not treat."

And they are not only those who already have infections that could be affected by the resistance, he said. "It will come back at a time when you can not do organ transplants because you will stay lifelong compromised for the rest of your life. You will not be able to save a premature baby, treat leukemia.

"What we think today as an absolute routine will disappear or if it does not disappear, is extremely risky."

& # 39; The Highest Threat to Health Care & # 39;

Both Vright and Morris emphasize the need for joint action to stop the resistance resistance, which means that federal and provincial governments take the lead in coordinating innovative programs to encourage the development of antibiotics, finding alternative treatments and restricting abuse and overuse.

"We are really at this perfect level of storm and filtered for every Canadian Canadian Canadian population – but this does not affect the Canadian population on a daily basis, but everyday Canadians are getting hit and will make things worse," Morris said.

By forbidding a world war or some disastrous virus that appeared, "I think the greatest threat to health concerns worldwide is absolutely antimicrobial resistance."

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