Friday , August 12 2022

A single protein leads to the growth and spread of the deadliest cancer, research shows


Addiction to a single protein can be the key to alleviating one of the deadliest carcinoma in the world, research shows.

Scientists have found that a particularly aggressive subtype of pancreatic cancer requires a molecule to grow and expand.

They are now considering ways to reduce protein, TP63, in order to increase the risk of survival of patients with diseases.

If we can prevent it from happening ever, it could be really good for the survival of this most vulnerable group of cancer patients

Pancreatic cancer, which affects nearly 10,000 people every year in the UK, has a bad reputation as one of the deadliest carcinoma.

On average, a patient with pancreatic cancer will survive only two years after diagnosis.

But some individuals with a particularly aggressive subtype of the disease often undergo even earlier, after less than a year.

American researchers who investigated this super-deadly subtype from pancreas found that the gene for TP63 is uniquely active in its tumor cells.

Writing in Cell Reports, they point out that the molecule does not belong to the pancreatic cells.

P63 usually plays a role in the production of squamous cells, the long thin cells needed to form the skin.

But in pancreatic tumors, the cancer protein version – TP63 – raked out of control growth and helped the disease spread around the body.

The good news was that cancer looked like a molecule for its current survival, increasing the hope for the development of targeted treatments.

Lead scientist Dr. Timothy Somerville of Cold Spring Harbor in New York said: "Cancer cells become so reliable at P63 that they really require P63 for their continuous growth.

"So, moving forward, we are looking for approaches to suppress inadequate P63 activity as a treatment option for patients."

Another goal for this is to find out why the gene is activated in the pancreas.

"If we can stop it from any event, it could be really good for the survival of this most endangered group of cancer patients," Dr Somerville said.

– Press Association

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