Wednesday , October 27 2021

Zavadsky explains whether it is currently possible to detect sufficient levels of antibodies to protect against Covid-19.


Head of the Family Vaccination Center at the Children's Clinical University Hospital, pediatric infectologist Dace Zavadska.

Head of the family vaccination center at Children’s Clinical University Hospital, Dace Zavadska, pediatric infectologist.

Photo: Paula Čurkste / LETA

It is not yet possible to determine the level of antibodies that will protect against Covid-19, said Charlotte Konova, spokeswoman for the National Immunization Council (NWP) secretariat.

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IVP President Dace Zavadska stresses that allegations or intentions to test antibodies are increasingly being made in the public sphere to ensure that antibody levels against Covid-19 have been maintained. high enough over time.

“Currently, these tests are not necessary and do not provide meaningful information,” Professor Zavadska stresses. The IVP recalls and explains why antibody clarification is not currently useful.


It is not yet possible to determine whether a particular level of antibody is sufficient for immune protection and how long the CoV-2 SARV infection has. For this to be possible, the so-called specific number or number of specific antibodies (immune protection correlate) in infectious diseases and immunization is essential, which reliably confirms not only the adequacy of protection, but also its sustainability. .

“For SARS CoV-2 infection and Covid-19 disease, this number of specific antibodies has not yet been determined, either after the disease or after vaccination,” Professor Zavadska stressed on behalf of the ‘IVP.

He points out that a large amount of international and national research is currently being carried out on this subject, Latvia also participates in larger groups of researchers, but so far it has not been possible to establish.

Consequently, any antibody test result cannot answer the question of whether the level of antibody is sufficient for protection and for how long.

The IVP explains the importance of knowing that neutralizing and binding antibodies are used to analyze the antibody response and make reliable comparisons. Methods for the detection of these antibodies are usually available for research in specialized laboratories.

Other methods widely available and used in Latvia, including stationary antibody detection methods, cannot be used to compare the results with the results mentioned in the literature and scientific publications.

The professor notes that it is important to understand that the immune response and protection against Covid-19 vaccines are broad and include both humoral or antibody response as well as protection against cellular immunity.


The reduction in the number of antibodies in the periphery or in a blood sample drawn from a vein does not reflect the true antibody response to the virus, and at this time the protection is provided by the combination of both types of immune response. (T and B cells or protection against cells and antibodies). The protection provided by the cells and the measures that reflect them in the studies indicate that it is stable for at least six months and more after primary vaccination.

“Finally, vaccines registered against Covid-19 still offer good protection against hospitalization, serious illness, and death, even in various professional groups,” Zavadska recalls once again.


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