Saturday , August 20 2022

IPN scientists are designing drugs for the treatment of Alzheimer's disease



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Scientists at the National Polytechnic Institute (IPN) have designed a multi-objective compound that works on three pharmacological targets of Alzheimer's disease, said Martha Cecilia Rosales Hernandez, who led the research at the Medical School (ESM).

He explained that the substance was evaluated in cell lines and animal models and was found to have very similar effects with a compound called galantamine, which is currently used to treat this condition in mild and moderate phases.

The expert pointed out that Alzheimer's disease is a severe diagnosis, as it often confuses with senile dementia, although there are no precise diagnoses in Mexico, it is estimated that this affects between six and nine percent of the population older than 60 years.

He added that the multi-objective compound improves memory because it is able to inhibit the acetylcholinesterase enzyme, increases acetylcholine within the synapse and increases neurotransmission.

Rosales Hernandez said the developed product is trying to prevent the aggregation of the beta-amyloid peptide, which produces senile plaques and some pro-inflammatory molecules that produce reactive oxygen species, in the same way.

In order to understand the behavior of beta-amyloid peptide, IPN researchers calculate molecules interacting with it, which allows them to have specific structures aimed at avoiding peptide aggregation.

Functioning of molecules is estimated using calculating tools, and three or five are selected with better activity, a process that saves time and money in research.

Rosales added that until now there are no medications that target several targets and that pharmacokinetic tests, toxicity studies and lethal doses in animals continue to be required before moving into the clinical phase.

He explained that Alzheimer's multiple neurodegenerative process of the central nervous system, clinically characterized by the progressive loss of short-term memory and attention, followed by the inclusion of other cognitive skills such as language, abstract thinking, critical interpretation and recognition of places or people.

In the meantime, neurotic plaques or senile plates (highly toxic to neurons) have deteriorated deposits of Beta-amyloid proteins that are formed extracellularly in the intraneuronal spaces of gray matter of the brain, mainly in the hippocampus and prefrontal cortex involved in memory and emotional control.

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