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The updated recommendations on the HPV vaccine follow the major drops of HPV infection in a new study



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The updated recommendations on the HPV vaccine follow the major drops of HPV infection in a new study

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On August 28, 2006, a photo file, a doctor keeps a bottle of Gardasil's human papilloma virus (HPV) vaccine in his Chicago office. (AP Photo / Charles Rex Arbogast, file)

ASSOCIATED PRESS

It is now recommended that adults under 45 talk with their doctor about the human papilloma virus (HPV) vaccine, which prevents 3% of all cancers in women and 2% of all cancers in men . Approximately 34,000 cancers per year in the United States. After confirmation by the director of the Centers for Disease Control and Prevention (CDC), the recommendations also refer to the age of men ages 21 to 26, as well as to women.

The decision of the Advisory Committee on Immunization Practices (ACIP) of the CDC on July 26 came the same day The spear published the most important study so far on the efficacy of the vaccine. The meta-analysis of 65 studies found decreases between 31% and 83% of HPV infections and genital warts in men and women, according to age and diagnosis.

HPV is responsible for almost all cervical cancers, more than 90% of anal cancers, 70% of cancers of the mouth, throat and neck, and more than 60% of penile cancer. Although HPV is transmitted mainly through sexual contact, there is also a non-sexual transmission.

Previously, the HPV vaccine had been recommended for women and men in a series of doses up to 14 years or three doses of up to 26 years for women and 21 years for men. Men ages 22 to 26 could also be vaccinated.

The unanimous vote of ACIP in favor of the extension of the 26-year recommendation for men is a test of substantial benefits for men. In fact, research shows that men are six times more likely than women to develop an oral infection with high-risk strain of HPV.

The votes between 10 and 4 ACIP for adults between 27 and 45 years old who did not receive the HPV vaccine insist on making decisions shared with their providers. The HPV vaccine is not approved by the FDA for adults over 45 years old because there is no effective data for this age group.

The "ACIP decision indicates that the data showed" that the HPV vaccine is safe and effective in patients aged 27 to 45 and that their use in this age group should be the The result of "Decision-making shared between patients and their trusted doctors," said Christopher M. Zahn, MD, vice president of practice activities at the American Association of Osteologists and Gynecologists (ACOG) .

"It tries that gynecologists and obstetricians discuss with their patients from 27 to 45 years the potential benefits of vaccination against HPV, trying to reduce the effectiveness versus vaccination in the younger age group And this reduced risk of high-grade disease and cervical cancer, "Zahn said, adding that receiving the recommended age-range vaccine from 11 to 12 years offers the greatest benefit.

"Women's decisions will also take into account their personal circumstances, preferences and concerns, and the role of obstetrician-gynecologist is to provide unbiased, balanced and comprehensive information to facilitate this decision-making. He said.

New research reveals major decreases in HPV-related infections

The new study found that HPV infections in strains 16 and 18 decreased 83% in girls 13 to 19 years of age and 66% in women 20-24 years after vaccination.

The HPV strains of 16 and 18 of Gardasil account for 70% of cancers of the cervix, the vagina, the vulva and the anus. Gardasil 9 also protects against HPVs 6 and 11, which cause 90% of genital warts and against five other strains (31, 33, 45, 52, and 58). Together, the Gardasil 9 strains represent 90% of HPV-related cancers.

According to the new study, HPV infections caused by HPV 21, 33 and 45 were reduced to half (54%) among girls vaccinated from 15 to 19 years old. In the same way, the diagnoses of genital warts decreased 67% for these girls and 48% for boys of the same age. Older men (up to 24 years old) and women (up to 29 years old) also experienced a 31% to 54% decline in genital warts.

The rates of cervical neoplasm of degree 2, a cancer precursor, were also reduced by half (51%) among girls aged 15 to 19 and 31% among women aged 20-24.

Cervical cancer can take up to 20 years to develop, so the vaccine, approved for the first time in 2006, has not been available long enough to be a factual base that is quite important to show a reduction in the incidence of cervical cancer. incidence of cancer However, the dramatic decrease in rates of HPV infection should produce a similar decrease in cancer rates caused by HPV and immunity against vaccine is sustainable.

Several important revisions of the HPV vaccine have found that it is one of the safest vaccines available. Although the stroke itself can be especially painful, the only regularly reported side effects are pain, redness and pain at the site of the injection and, in some adolescents, temporary fainting, common in many teenage vaccines. . Of the 13,000 people who participated in the clinical trials of Gardasil 9, five also reported fever, allergy to the vaccine, asthma attack, headache and tonsillitis, although not all were identified by the vaccine

The most effective way to reduce cervical cancer has been and remains the subject of periodic testing. However, screenings detect only the early development of abnormal tissues that can become cancerous, whereas the HPV vaccine avoids viral infections that cause these tissue alterations.

As there is currently no way to look for throat / mouth / neck cancer or anal cancer in women or men (or human penile cancer), the HPV vaccine remains the only way to prevent these cancers.

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On August 28, 2006, a photo file, a doctor keeps a bottle of Gardasil's human papilloma virus (HPV) vaccine in his Chicago office. (AP Photo / Charles Rex Arbogast, file)

ASSOCIATED PRESS

It is now recommended to adults under the age of 45 request medical attention to the human papillum virus (HPV) vaccine, which approximately a year prevents the United States. After confirmation by the director of the Centers for Disease Control and Prevention (CDC), the recommendations also refer to the age of men ages 21 to 26, as well as to women.

The decision of the Advisory Committee on Immunization Practices (ACIP) of the CDC on July 26 came the same day The spear published the most important study so far on the efficacy of the vaccine. Decreases were found between 31% and 83% of HPV infections and genital warts in men and women, according to age and diagnosis.

HPV is responsible for almost all cervical cancers over and over again. Although HPV is transmitted mainly through sexual contact, it also occurs.

Previously, the HPV vaccine had been administered to women and men in a series of doses up to 14 years or up to three doses. Men ages 22 to 26 could also be vaccinated.

The unanimous vote of ACIP to extend the recommendation to 26 years in men is evidence of the presence of the vaccine. In fact, research shows that men are more likely than women to develop an oral infection with the high risk strain of HPV.

The votes between 10 and 4 ACIP for adults between 27 and 45 years old who did not receive the HPV vaccine insist on making decisions shared with their providers. The HPV vaccine is not approved by the FDA for adults over 45 years old because there is no effective data for this age group.

"The ACIP decision underlines that the HPV vaccine is safe and effective in patients aged 27 to 45 years and that the use of the vaccine in this age group should be the result a decision shared between patients and their patients with confidence, said the doctors in a statement, "said Christopher M. Zahn, MD, vice president of practice activities at the American College of Osteometrics and Gynecologists (ACOG).

"It tries that gynecologists and obstetricians discuss with their patients from 27 to 45 years the potential benefits of vaccination against HPV, trying to reduce the effectiveness versus vaccination in the younger age group And this reduced risk of high-grade disease and cervical cancer, "Zahn said, adding that receiving the recommended age-range vaccine from 11 to 12 years offers the greatest benefit.

"Women's decisions will also take into account their personal circumstances, preferences and concerns, and the role of obstetrician-gynecologist is to provide unbiased, balanced and comprehensive information to facilitate this decision-making. He said.

New research reveals major decreases in HPV-related infections

The researchers found that HPV infections in strains 16 and 18 decreased 83% in girls 13 to 19 years of age and 66% in women aged 20 to 24, up to eight years after vaccination.

The HPV strains of 16 and 18 of Gardasil account for 70% of cancers of the cervix, the vagina, the vulva and the anus. It also protects against HPV 6 and 11, which causes and against other five strains (31, 33, 45, 52 and 58). Together, the Gardasil 9 strains represent.

According to the new study, HPV infections caused by HPV 21, 33 and 45 were reduced to half (54%) among girls vaccinated from 15 to 19 years old. In the same way, the diagnoses of genital warts decreased 67% for these girls and 48% for boys of the same age. Older men (up to 24 years old) and women (up to 29 years old) also experienced a 31% to 54% decline in genital warts.

The rates of cervical neoplasm of degree 2, a cancer precursor, were also reduced by half (51%) among girls aged 15 to 19 and 31% among women aged 20-24.

The development of cervical cancer can take up to 20 years. Therefore, the vaccine was not available long enough to provide a fairly large database that showed a reduction in the incidence of cancer. The drama, however, should translate into similar drops in cancer rates caused by HPV, i.

They have found several vaccines against HPV among available vaccines. Although the stroke itself can be especially painful, the only regularly reported side effects are pain, redness and pain at the site of the injection and, in some adolescents, temporary fainting, common in many teenage vaccines. . Of the 13,000 people who participated in the clinical trials of Gardasil 9, five also reported fever, allergy to the vaccine, asthma attack, headache and tonsillitis, although not all were identified by the vaccine

The most effective way to reduce cervical cancer has been and continues to be. However, screenings detect only the early development of abnormal tissues that can become cancerous, whereas the HPV vaccine avoids viral infections that cause these tissue alterations.

As there is currently no way to look for throat / mouth / neck cancer or anal cancer in women or men (or human penile cancer), the HPV vaccine remains the only way to prevent these cancers.

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