A few days ago there was a great controversy with medicine – NOLOTIL – used in medicine for decades. It's ridiculous that people put aside medicines and do not follow medicine simply because they have heard or seen the news …
We break controversy from credible sources!
(Who can consult)
Basically, he Nolotyl has its active ingredient magnesium metamizole. Substance sold in Portugal and other brands. In particular, Dolocalma like in Cinnamon Metamizole i Metamizol Sandoz, the last two generic drugs.
Metamizole is a spring that spontaneously decays into compounds structurally linked to pyrazolone. In short, it is a popular analgesic drug, do not opioid
Magnesium metamizole has an analgesic (anti-pain), anti-inflammatory (inflammation) and antipyretic (for fever). Particularly acute pain in the postoperative or post-traumatic period. Spasmodic pain. A severe fever that does not respond to other antipyretic therapies. Pain in the tumor.
Analgesic scale (by the World Health Organization):
The use of pain control medicines is based on the principle of using analgesic ladders in three stages based on:
- Nonsteroidal antiinflammatory analgesic drugs and other analgesics (paracetamol and metamizole),
- Opioids labeled as weak (codin or tramadol),
- Opioids designated as strong (morphine, buprenorphine or fentanyl)
On any of these steps, adjuvants may be added, such as antidepressants,
anti-convulsions and others.
These medicines aim to prevent the excessive use of opioids, which can lead to tolerance and addition of the phenomenon.
Despite being considered an analgesic of proven efficacy, metamizole, like most drugs, has negative effects!
However, on health workers, namely doctors who prescribe blood-level blood analysis (blood-flow) and balance risk-benefit.
Therefore, its use depends on a careful assessment of the risk and benefit relationship taking into account available alternatives.
Well, metamizole has been withdrawn from the markets of the United States and several European countries after reports of fatal agranulocytosis among users! However, it is available in many countries of Europe, South America and Asia
But what is agranulocytosis after all? What caused death?
Agranulocytosis is a medical expression for the reduction of granulocyte-leukocyte cells (immune system) such as neutrophils.
These cells are responsible for "initial combat" against foreign agents or pathogenic particles. However, the reduction of these cells increases the risk of contagious infectious disease.
In short, this led to death and, consequently, withdrawal of drugs in other countries!
Why is it still being marketed in Portugal?
According to the words Infarmed, "The use of drugs that contain this substance can cause an adverse reaction – agranulocytosis – which, although serious, is very rare"
"In Portugal, a total of 11 cases of agranulocytosis potentially associated with the use of metamizole were reported by the pharmacovigilance system between 2008 and 2018, with a frequency of 1 to 2 cases per year (which is a very rare reaction within the expected incidence)."
In order to avoid such reactions, Infarmed advice is used "limited for a short period of time" within a maximum of seven days.
If the use is longer than this, it is advisable to monitor the values of the homogram, a review that evaluates and counts the blood cells of the patient.
"These drugs should not be used in patients with haematological reactions prior to metamizole, in the treatment of immunosuppressants or other medical products that can cause agranulocytosis": "Special attention should be paid to prescribing these drugs in elderly patients," he warned.
Despite this warning, Infarmed warns that "patients who are prescribed metamizole should not stop treatment": "You should consult your doctor immediately if there are signs and symptoms of a blood disorder such as general illness, infection, persistent fever, bruises, bleeding or pale ".
To conclude, there is a risk for the population – people who are at risk of infection and related problems!
However, you can always freely ask your doctor not to prescribe this medicine and replace it with another alternative for the same therapeutic purpose. (After all, try not to cost!)
However, read also:
Sources: 1, 2, 3, 4, 5