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A Slovenian London investigator, Jernej Ule, received European money for brain research



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Brain. Photo: Laboratory Ule

About the contest ERC Advanced subsidy 2018 There were more than 2,050 applications for established researchers, of which 11% were selected for funding, which attests to the significant success of the Slovenian researcher, the director told the press conference. Chemical Institute Gregor Anderluh.


Jernej Ule Photo: Jernej Ule

They will catch up with funds ERC– Has established a new research group at the Institute of Chemistry, in which, according to Anderluh, approximately six to eight researchers Department of Molecular Biology i nanobiotechnology. A part of the project will also be carried out at the school University College London (UCL).

Investigate the functioning of the brain
A five year project entitled RNP Dynamics will investigate how the regulation of molecules is made RNA It contributes to the development and functioning of the brain and how the errors in this regulation are managed neurodegenerative diseases like amyotrophic lateral sclerosis (ELA), a researcher and Slovenian teacher molecular neuroscience on UCLUle.

In addition, the project will examine how the errors in the contacts take place proteins in RNK (ribonucleic acid) damage the action neurons and therefore trigger the disease ELA. This will be the basis for the development of new strategies for the treatment of diseases by means of RNA molecules.

According to Anderlech, this is a basic research project in which they will not develop medication ELA, but they understand better the reasons why this disease occurs. "I am convinced that the results of the project will be the basis for the development of medications and strategies to treat this disease in the future" said Anderluh.

The research will be based on techniques that control the entire cellular network of contacts between molecules, which will produce a large amount of data. These data will be the basis of computer analyzes that will look for changes in the molecular contact, which are key to the dynamics of the molecular complexes and, therefore, will lead to the early development of the brain.

Researchers from the Institute of Chemistry will cooperate mainly in the field of structural biochemistry and structural chemistry, thus helping to understand the structure and interaction of molecules and in the field of computer modeling processes that take place in the molecules of our body.

Jernej Ule in the background of the ERC call

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The Uletov project is eighth ERC-a project carried out in an organization of research in Slovenia and a fifth project in a scheme for established researchers. He is the second Slovenian ERC-Project at the Chemical Institute, first, with the title MaCChines, won last year Roman hérala.

Anderluh also presented the project in the program during the event Marie Curie Skodlowska Actions –Single Scholarships Researchers from India and Italy and research teams that will soon be installed in their laboratories.

As he said, this year is also planned to modernize the scientific research teams within the framework of the Institute National downtown for NMR, High Definition Spectroscopy and the purchase of a new one cryoelectronics a microscope that will be unique to region. It will allow to investigate the structures of macromolecules and biological complexes with atomic resolution and, therefore, "significantly facilitated research capacity in the field of life sciences"said Anderluh.

At the moment of the presentation of the microscope, they will prepare a symposium at the Institute of Chemistry, where they will receive the Nobel Prize Joachim Franck. This is 2017 along with researchers Jacques Dubochet in Richard Henderson He received the Nobel Prize in Chemistry for Development cryoelectronics microscopy


The Slovenian publication Nature: how the cell directs the film of life

How the cells of the brain regulate the expression of the genes
The Slovenian researcher Jernej Ule graduated from the Biotechnology Faculty of Ljubljana and then received a doctorate from the Rockefeller University of New York in 2004. In 2006 he created a research team in England, first in Cambridge and now teacher molecular neuroscience on UCL in London, and leads the Francis Crick Institute research group.

It is about how contacts between proteins and molecules are formed RNA And how is this important in the expression of genes. During his doctorate, he developed a new technique for this purpose, which is said to be CLIP, and his group developed more versions, such as iCLIP in hiCLIP. With these techniques, it examines how brain cells regulate the expression of genes.

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