Clinical use against autoimmune diseases, allergies and cancers
"autoimmune diseases and allergies are among the most commonly occurring diseases around the world, and therapies are urgently needed. Here is ours discovery be extremely useful. If you are BH4 inhibits, we can inhibit the constant attack of these auto-aggressive T cells, so that they do not destroy healthy tissue or cause chronic inflammation, "he said. Shane Cronin, Postdoc at IMBA and the first author of the current publication in the nature,
Clifford Voolf from the Children's Hospital in Boston Harvard i Kai Johnsson. Mak Planck Institute for Medical Research, Heidelberg, researchers have developed a new drug called KM385 BH4 inhibits, and immune cells with a bad overload of "darkness." The first clinical studies were defective.
BH4 also for cancer therapy?
BH4 At the same time, it is also an important candidate for future immunotherapy of the cancer, because activated T cells detect and fight cancer cells. The researchers found this in mice BH4 T cells help to guide the tumor. It also turned out to be a phenomenon BH4 can be blocked with quinurenine, a molecule that is immune system can be excluded in tumors. Gift from BH4 It allows T cells to grow again.
Valuable knowledge of relationships
"Knowledge about new relationships in biology and the emergence of diseases is especially valuable because the applications can be very diverse. immune system Controls a molecule known from neurobiology and possibly new applications autoimmune diseases, Asthma can even lead to cancer and immunodeficiency! ", He said Shane Cronin,
"If you can find cross-links of various biological systems in the body, as in this case, the nervous system and immune system, sometimes you can get out discoveries yes. "In the past, it was a team Josef Penninger Using the RANKL signaling pathway, it was possible to link bone metabolism and hormone system. The therapeutic use of the obtained dinazumab drug chain from bone loss to the breast cancer pill, currently in
Austria has been tested.