Thursday , July 7 2022

Vaginal bacteria related to ovarian cancer



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Having too few vaginal "friendly" bacteria may increase the chances of ovarian cancer in a woman, and carabiners can be used to detect it, researchers say.

The team, led by University College London, hopes that the finding can be used to identify women with a high risk of cancer, which has no detection test.

However, they say that more work is needed to explore it.

It's too early to recommend to women that they give protective doses of good bacteria, they say.

The work, which is published in The Lancet Oncology, was funded with money from the government capsule tax, as well as EU subsidies and the beneficial instance of Eve Appeal.

About ovarian cancer

Every year, in the United Kingdom, more than 7,300 women have been diagnosed with ovarian cancer.

Early diagnosis improves the chances of satisfactory treatment, but the symptoms – discomfort and discomfort – can be confused with more common and less serious diseases, such as menstrual cramps or irritable bowel syndrome.

Many women are not diagnosed until the cancer has begun to spread.

If your doctor thinks that the symptoms may be due to ovarian cancer, blood tests and scans are recommended.

The exact cause of ovarian cancer is unknown, but certain factors increase the risk of women: age, family history of ovarian or breast cancer and overweight.

Now researchers believe that microorganisms that live in our body can also play an important role.

Microbioma link

There is growing scientific evidence that the community of bacteria and other microbes that reside in our interior – our microbiome – influences our well-being and health.

A kind of beneficial bacteria that is believed to be particularly important in the vagina is called lactobacillus.

Experts believe that it prevents other unfamiliar or bad microbes from being resident and causing damage.

The study included 176 women with ovarian cancer, 109 with inherited genes of high risk for ovarian cancer (BRCA1 genes) and 295 women without known genetic risk.

Women were examined and samples were taken using the same method of harvesting that was used in cervical screening.

Lactobacillus levels were significantly lower in women under 50 years of age with ovarian cancer or high risk genes.

What do the results mean?

It is not clear if this link is causal or if other factors could explain it, or how much impact it has on the risk.

Helen Callard, from Cancer Research UK, said: "The microbiome is a very interesting area of ​​research and, little by little, we approach how natural bacteria can affect our health. Causality.

"There are several factors that can influence the risk of ovarian cancer and different things that may affect the composition of vaginal bacteria, and it is not always easy to separate these elements. Therefore, we must know how vaginal bacteria can directly affect the risk of developing ovarian cancer. Or if it is a completely different factor. "

Alexandra Holden of Target Ovarian Cancer said: "Before women worry about bacteria in their vagina, more research is needed to better understand how vaginal microbiomas can contribute to ovarian cancer and find better ways To detect the disease. Meanwhile, it is crucial that women realize the symptoms and visit the head doctor with any concern. "

Researchers believe that good errors provide a protective barrier to other infections, which prevents them from traveling to the gynecological tract in the fallopian tubes and ovaries.

The researcher, Professor Martin Widschwendter, said: "We still do not know for sure if the low levels of beneficial bacteria lead to a higher risk of ovarian cancer, but this is what we suspect.

"It adjusts to other investigations. It has shown that women who use excessive vaginal hygiene products also have lower levels of this bacterium and have a higher risk of cancer of the # 39; ovary ".

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